Vitamin C

Vitamin C or Ascorbic Acid is a water-soluble vitamin, which acts as a cofactor in numerous enzymatic reactions. It is also involved in the metabolism of cholesterol and bile salts, neurotransmitters and antioxidant activity.
Intravenous administration of vitamin C provides higher doses than oral administration, where amounts of more than 3-5 g daily can cause intestinal irritation.

Benefits of vitamin C in chemotherapy-resistant cancer

The Department of Translational Oncology of the Fundación Jiménez Díaz in Madrid carried out research on Vitamin C. Its ability to reduce tumor resistance to conventional therapies (chemotherapy) by modulating aberrant metabolism was studied.

The research was managed by the Quirónsalud health group, and its Health Research Institute (IIS-FJD). It was also supported by the Universidad Católica San Antonio de Murcia (UCAM).

The study then detected a surprising and previously unreported role of vitamin C in the regulation of pyruvate dehydrogenase (PDH) activity and its action against the KRAS gene mutation.

Dr Óscar Aguilera, senior research scientist in OncoHealth’s Translational Oncology Department, explained the work:

“We think that metabolic modulation of the tumor can make it much more sensitive to chemotherapy and could significantly increase patients’ life expectancy and improve their quality of life.”

“The almost complete absence of serious side effects of vitamin C in megadoses invites clinical trials with patients in combination with various pharmaceutical molecules of interest.”

Vitamin C and chemotherapy resistance

The authors of the study highlight resistance to conventional chemotherapy and anti-EGFR biologic therapies as the major obstacle facing oncology. The approach of new adjuvant treatments, such as Vitamin C, represents a real progression in cure statistics and in the reduction of cancer mortality.

References

Article published in: https://international.ucam.edu/university-news/significant-advances-effectiveness-vitamin-c-treat-persistent-cancers

More information

You can access the medical study at the following link:

Cenigaonandia-Campillo A, Serna-Blasco R, Gómez-Ocabo L, Solanes-Casado S, Baños-Herraiz N, Puerto-Nevado LD, Cañas JA, Aceñero MJ, García-Foncillas J, Aguilera Ó. Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer. Theranostics 2021; 11(8):3595-3606. doi:10.7150/thno.51265. Available from https://www.thno.org/v11p3595.htm

For more information, you can visit our website.

Skin Cancer Treated with Oncothermia and Intravenous Vitamin C

The following is a case report of a 75 year old male patient. The diagnosis is skin cancer. He was treated with oncothermia, combined with intravenous Vitamin C nutrition.

Diagnosis

In April 2019, the patient presented with skin cancer. In particular, a basal cell carcinoma on the left wing of the nose.

Basal cell carcinoma is the most common type of this cancer. It presents in the form of an ulcer with non-healing scabs that progressively increases in size. Treatment consists of surgical resection, leaving the margins free to avoid recurrence.

At the Oncothermia Unit in Barcelona we carry out coadjuvant treatment for these medical cases.

Treatment

Accordingly, she undergoes 15 60-minute Oncothermia sessions, with a frequency of 2 sessions per week, together with intravenous Vitamin C nutrition.

Result:

After completing the treatment the basal cell carcinoma disappeared completely.

If you wish, you can find more information about cancer treated with Oncotermia on our website, you can consult this link.

Vitamin C

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