Colon cancer

Colorectal cancer often begins as a growth, called a polyp, in the colon or rectum. It is possible to prevent colon cancer if polyps are detected and removed.

Medical history affects the risk of colon cancer.

Signs of colon cancer include blood in the stool or changes in bowel habits.

Tag Archive for: Colon

Effect of Oncothermia at the cellular level. Study in colorectal cancer xenografts

Researchers studied the effect of Oncothermia at the cellular level in the process of apoptosis in colorectal cancer cells.

The Department of Radiology of the Medicine and Pharmacy Faculty -University of Toyama, in Toyama, Japan- published in the journal CellStress and Chaperones (Springer) (Cell Stress Chaperones, 2015 Jan; 20 (1): 37-46 ) the results on the effect of Oncothermia in colorectal cancer cells.

Cell apoptosis

First of all, the use of modulated electrohyperthermia (mEHT) or Oncothermia, produces a modification of the electric field and the surrounding temperature of the tumor cell, leading to selective cell death (apoptosis) in malignant tumors without affecting healthy tissue. Certainly, this is possible due to the difference of a tumor cell compared with a healthy cell. Also, the tumor cell is characterized by high glycolysis, increased lactate production (Warburg effect) and reduced electrical impedance.

Oncothermia applied to colorectal cancer

Dr Andocs studied the effect of Oncothermia on HT29 xenografts of colorectal cancer (human colon cancer cells, inoculated in mice). Apoptosis caused by Oncothermia was mediated, predominantly, by the caspase cascade and the activation of the apoptosis inducing factor. The mEHT-related cell stresses studied 0-, 1-, 4-, 8-, 14-, 24-, 48-, 72-, 120-, 168- and 216-h. And post-treatment by focusing on damage-associated molecular pattern (DAMP) signals.

 Apoptosis response was after 4 hours from the treatment with Oncothermia. It was measured using the levels of messenger RNA (mRNA) levels of the “heat shock” proteins Hsp70 and Hsp90.


After that, the treatment resulted in spatiotemporal occurrence of a DAMP protein signal sequence featured by the significant cytoplasmic to cell membrane translocation of calreticulin at 4 h, Hsp70 between 14 and 24 h and Hsp90 between 24- and 216-h post-treatment.

Also, the release of high-mobility group box1 protein (HMGB1) from tumor cell nuclei from 24-h post-treatment and its clearance from tumor cells by 48 h was also detected.


In conclusion, the results suggest that mEHT treatment can induce a DAMP-related signal sequence in colorectal cancer xenografts that may be relevant for promoting immunological cell death response, which need to be further tested in immune-competent animals.

To conclude, the next experimental phase, which is to replicate the study in immunocompetent animals, is necessary.

Further information

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Ascending colon cancer treated with Oncothermia and Chemotherapy

The following is the clinical case of a 63-year-old male patient. The diagnosis is ascending colon cancer with liver metastases. He was treated with chemotherapy, combined with oncothermia.


In November 2016, he presented with an ascending colon neoplasm. Consequently, he underwent a right hemicolectomy. As a result, the biopsy showed infiltrating adenocarcinoma.

Subsequently, in January 2017, she presented with elevated CEA. A CT scan revealed mesenteric and retroperitoneal lymphadenopathy. Multiple liver metastases were also observed, the largest measuring 35 mm.


Immediately, in February 2017, he started treatment with chemotherapy (FOLFOX) and 4 sessions of 90-minute oncothermia.

The CT scan of April 2017 showed resolution of the mesenteric and retroperitoneal adenopathies. There was also a significant decrease in the multiple liver metastases, the largest being 14 mm.


Finally a normalisation of tumour markers is detected.

If you wish, you can find more information about colon cancer treated with Oncothermia on our website at this link.